Five people were injured on Wednesday in a nine-vehicle collision on the R59 south-bound highway in Sasolburg.
Paramedics were alerted at 5am, said Russel Meiring of ER24.
The vehicles, including trucks, were blocking the entire south-bound section of the highway.
Of the vehicles' occupants, five had sustained injuries ranging from minor to serious.
One patient had already been transported privately to a nearby hospital before the arrival of paramedics.
"It is believed that the heavy morning mists played a contributing factor to the cause of the collision," said Meiring. "Local authorities were on the scene for further investigations."
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